Endocrine Abstracts

Background: Congenital hypogonadotropic hypogonadism (CHH), a clinically and genetic heterogenous sydrome, is caused by > 40 known loci whose mutations share the ability to cause defects in the ontogeny of the GnRH neuron network leading to absent/incomplete puberty and infertility. Cornelia de Lange Syndrome (CdLS) is similarly heterogenous disorder (distinctive facies, psychomotor delay, growth retardation and upper limb malformation) caused by mutations in 7 different g...

Introduction: The prevalence of cardiovascular disease in reproductively active women has received limited attention. Recent data indicated possible adverse effect of non-typical obstetrical risk factors with regards to cardiovascular function. We aimed to evaluate the potential association between anti-mullerian hormone (AMH), a known marker of ovarian reserve, with subclinical atherosclerosis in young premenopausal women.Methods: This was a cross-secti...

Introduction: The aim of this study was to investigate the association between the genetic background of coagulation factors and the presence of oligo- or amenorrhea in adolescent girls diagnosed with anorexia nervosa compared with controls.Patients and Methods: A total of 40 adolescent girls diagnosed with anorexia nervosa aged 14–17 years, as well as 10 age-matched girls, were included in the study. We recorded anthropometric parameters and calcu...

Introduction: The National Osteoporosis Guideline Group (NOGG) recommends determine BMD in patients who present an intermediate risk of osteoporotic fracture using the FRAX® tool, follow-up for low risk, and treatment for high risk. In 2011, 3163 BMD were performed in the Complejo Asistencial Universitario de León (CAULE). Since the cost for each BMD is 58.6* (BOCYL 31/01/2011), annual spending could rise to *185 352. The aim was to assess whether fracture risk calcu...

Introduction: Thyroid dysfunction, whether overt or subclinical, has a significant effect on the cardiovascular system. On the other hand, fluctuation of thyroid hormones within the normal range has been associated with long-term health risks, and might have an impact on the vasculature. This study assessed the effect of thyroid hormones on surrogate markers of arterial structure and function in a sample of euthyroid postmenopausal women.Methods: This cr...

Background: Non-alcoholic fatty liver disease (NAFLD) is a very common liver disorder associated with insulin resistance and the metabolic syndrome. Insulin resistance is also a prominent feature even in lean women with the polycystic ovarian syndrome (PCOS). The objective of this study was to identify the presence of NAFLD in young lean women with PCOS.Methods: Fifteen women with PCOS and 10 controls participated in the study.Mean...

Background: Infertility is a common problem and the number of couples receiving assisted reproductive treatment (ART) is increasing. Using GnRH agonists (GnRHa) to trigger oocyte maturation has been shown to reduce risk of ovarian hyperstimulation syndrome (OHSS), a common complication of IVF, compared to the more traditional use of human chorionic gonadotropin (hCG). Kisspeptin has recently been shown to be a safe trigger of oocyte maturation in women at high risk of OHSS. Ki...

Introduction: Treatment with sodium glucose co-transporter2(SGLT2) inhibitors was found to reduce the incidence of cardiovascular events in diabetic patients.Herein, we investigated the effects of long-term treatment with canagliflozin on atherosclerosis development in the aorta of Apolipoprotein E knockout (Apo-E(−/−)) mice as well as on biochemical and immunohistochemical markers related to atherosclerosis.Methods: At 4 weeks of ...

Background: The aim of the study was to assess the clinical features of gastric neuroendocrine neoplasms type 1 (GNEN1).Methods: We have analyzed the clinical data of the first 73 patients with GNEN1 from our registry.Results: The mean age(±S.D.) of the patients (51 (68.9%) females) and the mean follow-up were 55±12.3 years and 28.8±42.2months, respectively. All patients had sporadic tumors and all wer...

BackgroundRecent data have shown the anti-apoptotic effect of Chchd2 mitochondrial protein through the Bcl-2/Bax pathway in various cancers. Bax is regulated primarily by proteins-members of Bcl-2 family and mainly the Bcl-2 protein, which has been found to prevent Bax from accumulating in mitochondria. In response to apoptotic stimuli, Chchd2 decreases and loses its mitochondria localization accompanying by decreased Bcl-2/Bax interaction and increased ...